The role of estrogen receptor beta on severity of Recurrent Aphthous Stomatitis (RAS)

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Abstract

The aim of this study was to examine the expression of the estrogen receptor Beta (ER ???in female oral mucosa and to equate Oral Hygiene Index status (OHI-S) with the severity of minor recurrent aphthous stomatitis (RAS). The subjects (26 women, 17-40 years old, with minor RAS but no hormonal therapy or hysterectomy) were investigated to see the whether the severity correlated with the onset pattern, recurrence, level of pain, position, number of lesions, and OHI-S. The expression of ER β in the mouth was detected by immuno cytochemistry. Logistic regression was used to analyze the significance of factors related to the severity of minor RAS. The results showed a significant relation between ER β and the severity of minor RAS controlled by OHI-S (p<0.05), with the OR for ER β = 8.67. In conclusion, expression of ER β in oral mucosa may be related to the severity of minor RAS, reflecting the role of oral hygiene. Hence, maintaining oral hygiene is important for preventing the worsening of RAS.

Original languageEnglish
Pages (from-to)711-714
Number of pages4
JournalJournal of International Dental and Medical Research
Volume10
Issue numberSpecialissue
Publication statusPublished - 1 Jan 2017

Keywords

  • Estrogen receptor beta
  • Female oral mucosa
  • Recurrent aphthous stomatitis

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