The relationship of diabetes, periodontitis and cardiovascular disease

Anandhara Indriani Khumaedi, Rr. Dyah Purnamasari Sulistianingsih, Ika Prasetya Wijaya, Yuniarti Soeroso

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Cardiovascular complications in diabetic patients comprise of interaction between traditional and non-traditional risk factors. This interaction is thought to play role in four-times increment of cardiovascular mortality risk in diabetic patients, compared to non-diabetics. Chronic inflammation is known to be one of atherosclerosis non-traditional risk factor and has a role on every phase of atherogenesis. Periodontitis is the most common cause of chronic inflammation in diabetic patient. Both periodontitis and diabetes have detrimental effect on each other in terms of alveolar bone destruction and poor metabolic control, by continuous inflammatory mediator activation. Defect of bacteria elimination ability and monocyte hyper-responsiveness in diabetic patients leads to persistent elevation of systemic inflammatory mediators. This process give rise to prolonged and augmented exposure to inflammatory cytokines. This exposure interacts with traditional risk factor could lead to initiation of endothelial dysfunction, the first phase of atherogenesis.

Original languageEnglish
Pages (from-to)1675-1678
Number of pages4
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Cardiovascular
  • Diabetes
  • Periodontitis

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