The reduction effect of blood interleukin-6 concentration on aged Sprague-Dawley rats after Centella asiatica ethanolic extract administration

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Abstract

Aging is an inevitable time-related process leading to reduced cognition and physical strength also increased susceptibility of degenerative disorders. This study studies the aging process related to relatively high oxidative stress level and proinflammatory mediators such as interleukin-6 (IL-6). Centella Asiatica (CA), a traditional medicinal herb, has been widely reported to have an antioxidant and anti-inflammatory effect, both experimentally and clinically. The study investigates the impact of CA on aged Sprague-Dawley rats. Twenty-eight rats were divided into four groups: negative control, positive control (vitamin E 6 IU), treatment (CA ethanolic extract 300mg/kg body weight), and regular group (young Sprague-Dawley rats). After 28 days of treatment, the rats were terminated, and their blood IL-6 concentrations were assessed with enzyme-linked immunosorbent assay. We found that CA significantly reduced blood IL-6 concentration in the treatment group compared to negative control (p = 0.001). There was also no significant difference of blood IL-6 concentration between treatment group and positive control, which indicated that CA and vitamin E may be equipotent as an antioxidant and anti-inflammatory agent. These results suggested that CA may be a potential candidate for an antiaging agent in the next future.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • aging
  • centella asiatica
  • interleukin-6
  • oxidative stress

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