Tempe is a traditional native food of Indonesia, its patents filed by foreigners in the United States and Japan. This is harmful for Indonesia because in the future we are threatened to pay loyalty to patent holder when we produce according to the registered patents, especially when we export tempe to those countries. The purpose of this study is to gain understanding of how to protect and preserve knowledge of tempe for the welfare of people of Indonesia. Using a qualitative approach, the research is conducted through literature review concerning the preservation and protection of traditional knowledge of tempe. From the research it was identified that the government and people of Indonesia have raised objection about patented tempe by foreigners but they are still not effective to protect the intellectual property rights of our nation because they are not well organized. Now is the time for Indonesia government to take initiative to preserve and protect the intellectual property rights of tempe as one of Indonesian traditional knowledge.