The prognostic significance of phosphatase and tensin homolog loss in breast cancer

Indri Windarti, Wirsma Arif Harahap, Ricvan Dana Nindrea, Eti Yerizel, Primariadewi Rustamadji

Research output: Contribution to journalReview article

Abstract

AIM: This study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer. METHODS: We conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3). RESULTS: There were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included. CONCLUSION: This study confirmed PTEN loss is an important independent factor for breast cancer prognosis.

Original languageEnglish
Pages (from-to)3716-3720
Number of pages5
JournalOpen Access Macedonian Journal of Medical Sciences
Volume7
Issue number21
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Breast cancer
  • Immunohistochemical
  • Prognosis
  • PTEN

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