The profile of progesterone hormone, vitamin D, and bone density in postmenopausal women

Decreased levels of progesterone, which plays a role in preventing bone loss, may increase the risk for osteoporosis in postmenopausal women. Vitamin D plays a role in bone formation. This study aimed to analyze the relationship among progesterone, vitamin D, and bone density in postmenopausal women. This is a cross-sectional study involving 59 postmenopausal women. Levels of progesterone and vitamin D in blood samples were determined using ELISA. Bone density was measured using dental radiography. Subjects were divided into two groups: those aged < 60 years and those aged ≥ 60 years. Categories for levels of progesterone, vitamin D, and bone density were established on the basis of the receiver operating characteristic curve. Spearman correlation test showed no significant relationship (p > .05) between progesterone or vitamin D levels and bone density in either group. In conclusion, this study showed that neither progesterone nor vitamin D is significantly correlated with bone density in postmenopausal subjects.