The prediction, observation and analysis of a new form of cannabidiol

Lina Mardiana, Michael J. Hall, Michael R. Probert

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Cannabidiol (CBD) is a phytocannabinoid which has become increasingly important as an active pharmaceutical ingredient (API),and is commonly isolated and used in its well-known and stable crystalline form (Form 1). However, the crystal structures of a seriesof CBD analogues, containing a different number of carbon atoms in the alkyl sidechain at C-5’, shows that CBD Form 1 is anoutlier in a group demonstrating homologous isomorphism. This indicated the potential existence of an uncharacterised isomorphic CBD polymorph (Form 2).High throughput crystallisation techniques, namely the ENaCt protocol, were used in combination with CBD homologue seeding tosearch for the presence of this predicted Form 2 of CBD. Optical analysis of the resultant crystals suggested the presence of anew form due to block like crystals rather than the needles associated with Form 1. Single Crystal X- Ray Diffraction (SCXRD)analysis of these crystals of CBD resulted in a structural model with packing that fits with the isomorphic series. This experiment represents the first example of directed polymorph discovery using high throughput ENaCt techniques.
Original languageEnglish
Pages (from-to)a365-a365
JournalActa Crystallographica Section A: Foundations and Advances
Volume79
Issue numbera1
DOIs
Publication statusPublished - 7 Jul 2023
EventAbstracts of the 2023 American Crystallographic Association Meeting - Baltimore, United States
Duration: 7 Jul 202311 Jul 2023

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