The potential role of goat milk in regulating CD4+ and CD8+ T cells in ethanol 80%-induced gastritis: A research using a gastritis rat model

Gastritis, an inflammation in the stomach, is a result of several factors, including ethanol. In this investigation, rats were used as models in order to examine how goat milk affects the ratio of CD4+ and CD8+ immune cells in the stomachs of rats suffering from gastritis. This study aimed to examine how goat milk affects the ratio of CD4+ and CD8+ T cells in gastritis rat models induced by 80% ethanol. A pre-clinical design was employed in this experimental research. In this study, male Sprague Dawley rats were assigned to five groups. The control group did not receive 80% ethanol induction and no goat milk administration. The Etl 80% group included the rats which were induced by 1 ml of 80% ethanol for three days without goat milk treatment, while the rats in the GM 0.5 group, were daily administered 0.5 ml of goat milk for 30 days, and then induced by 1 ml of 80% ethanol. The fourth group, the 1 ml GM group, included the rats for which 1 ml of goat milk was daily given for 30 days, and then they were induced by 1 ml of 80% ethanol. The GM 1.5 group, the fifth group, included the rats for which 1.5 ml of goat milk was administered for 30 days, and then induced by 1 ml of 80% ethanol. In addition, blood samples were analysed by flow cytometry. The results showed that the groups administered 1.0 ml and 1.5 ml of goat milk per day for 30 days experienced an increase in the ratio of CD4+ and CD8+ T cells in comparison to the control (Etl 80%) group. The immune response in the stomach of gastritis rats induced by 80% ethanol in the goat milk administration is influenced by an increase in the ratio of CD4+ and CD8+ T cells.