The potency of hibiscus sabdariffa linn. on decreased memory function related to the level of bdnf and creb in hippocampus of overtrained rats

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Abstract

Athletes suffering from overtraining syndrome is quite high, and is often related to learning and memory disorders, caused by oxidative stress. This study was conducted to determine the molecular mechanism that bridges the preventive effect of learning and memory disorders by Hibiscus sabdariffa Linn. by measuring levels of BDNF and CREB in hippocampal tissue of rats given overtraining exercise. 20 male rats Rattus norvegicus (200-250 g) and 8-10 weeks of age were divided into 4 groups randomly, 1) the control group (C), 2) control group with H. sabdariffa (C-Hib), 3) group given overtraining aerobic exercise (OT), 4) the group treated as OT group plus the provision of H. sabdariffa dose 400 mg/kg/day (OT-Hib). There was a decreased memory function in the OT group based on the travel time and total number of error compared to the C and C-Hib group, although there was no significant difference in the travel time between the OT and the C and C-Hib group (p>0.05). The highest CREB level was found in the OT-Hib group that was significantly different with the OT group (p<0.05). There was a significant decrease of BDNF levels in the OT group and OT-Hib compared to the C-Hib group (p<0.05). In the OT-Hib group, the MDA levels still higher significantly and GPx levels lower significantly compared to C and C-Hib group (p>0.05). In overtraining rats, provision of H. sabdariffa can activate CREB but the BDNF still declined and memory function not much improved.
Original languageEnglish
Pages (from-to)17097-17103
JournalInternational Journal of Recent Scientific Research
Volume8
Issue number5
DOIs
Publication statusPublished - 6 Apr 2017

Keywords

  • Overtraining, H. sabdariffa, Memory, BDNF, CREB

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