The Potency of Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) as a noncollagen protein analog to dentine remineralization

Atria Mya Kelani, Nilakesuma Djauharie, Ratna Meidyawati, Endang Suprastiwi, Rivanti Irmadela Devina

Research output: Contribution to journalArticle

Abstract

Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) is a noncollagen protein analog material that may serve as a regulator of the intrafibrillar remineralization mechanism through the guided tissue remineralization (GTR) approach. Methods: Eight 3-mm depth demineralized cavities were divided into two groups: group 1 cavities were immediately filled with temporary restoration; while group 2 received CMC/ACP first and only then were filled with temporary restoration. All samples were immersed in phosphate buffered saline (PBS) and were stored in a 37 oC shaking incubator. Remineralization evaluation with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) was done on day seven. Results: In group 2, SEM images showed the presence of irregularity in dentinal tubules, and EDX analysis showed significantly increased calcium and phosphate levels in dentinal tubules. Conclusion: CMC/ACP has the potency to remineralize dentine.

Original languageEnglish
Pages (from-to)1258-1262
Number of pages5
JournalJournal of International Dental and Medical Research
Issue number4
Publication statusPublished - 1 Jan 2019

Keywords

  • CMC/ACP
  • Dentine
  • DMP 1
  • Noncollagen protein analogs
  • Remineralization

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