TY - JOUR
T1 - The Potency of Alpinia galanga as Natural Antioxidant
AU - Laksmitawati, Dian Ratih
AU - Pratami, Diah Kartika
AU - Widowati, Wahyu
AU - Kusuma, Hanna Sari Widya
AU - Wijayanti, Cahyaning Riski
AU - Rizal, Rizal
N1 - Funding Information:
This research was funded by the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia through the Grants-in-Aid Penelitian Terapan Unggulan Perguruan Tinggi 2021. The authors would like to express their gratitude to Seila Arumwardana and Muhamad Aldi Maulana of the Biomolecular and Biomedical Research Center in Bandung, West Java, Indonesia, for their invaluable assistance.
Publisher Copyright:
© 2022, Universitas Gadjah Mada - Faculty of Pharmacy. All rights reserved.
PY - 2022
Y1 - 2022
N2 - An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.
AB - An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.
KW - Alpinia galanga
KW - Antioxidant
KW - Free radicals
KW - Reactive Oxidative Species
UR - http://www.scopus.com/inward/record.url?scp=85152383298&partnerID=8YFLogxK
U2 - 10.22146/mot.72450
DO - 10.22146/mot.72450
M3 - Article
AN - SCOPUS:85152383298
SN - 1410-5918
VL - 27
SP - 165
EP - 171
JO - Majalah Obat Tradisional
JF - Majalah Obat Tradisional
IS - 3
ER -