The optimization of eluting condition of solid phase extraction method for α-mangostin purification in mangosteen pericarp extract

Febrina Amelia Saputri, Annisa Mayangsari, Muchtaridi Muchtaridi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: To obtain the optimum condition of eluent selection for purification of α-mangostin in mangosteen pericarp extract with solid phase extraction (SPE) method. Methods: The analysis was conducted by SPE cartridge octadecylsilane (ODS)-5, solvents used were methanol for conditioning, aqua bidestilated for washing and three different eluents for eluting: methanol, ethanol and ethyl acetate. Results: Recovery value for each eluent were 32.4741% for methanol, 46.6130% for ethanol and 33.6383% for ethyl acetate. Comparison of alpha-mangostin level in the mangosteen pericarp extract for each eluent i.e. 14.4578% for methanol, 10.0598% for ethanol, and 14.2898 % for ethyl acetate while compared to the extract without SPE was 21.7934%. Conclusion: Ethanol had the highest recovery value, compared to methanol and ethyl acetate.

Original languageEnglish
Pages (from-to)112-114
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue number3
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Eluent
  • Optimization
  • Solid phase extraction
  • α-mangostin

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