The mRNA expression of Forkhead box O3a (FOXO3a) as a longevity-associated gene in leucocytes of elderly women

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Abstract

OBJECTIVE: This study aimed to analyse the expression pattern of FOXO3a in leucocytes of elderly women according to their lifespans. Methods: It was a cross-sectional study involving 60 healthy elderly female subjects living in Jakarta. Women were classified based on age as younger (60-70 years of age) and older (> 70 years of age). Blood samples were taken for the preparation of leucocyte cells for RNA isolation. FOXO3a mRNA expression was analysed using quantitative polymerase chain reaction (qPCR). RESULTS: The relative mRNA expression of FOXO3a in leucocytes was significantly higher in the younger group (60-70 years of age) than in the older group (> 70 years of age). CONCLUSIONS: FOXO3a mRNA expression decreased with increasing age in elderly female subjects. Further research is required to evaluate FOXO3a expression at the protein level.

Original languageEnglish
Pages (from-to)S74-S77
JournalJPMA. The Journal of the Pakistan Medical Association
Volume71 2)
Issue number2
Publication statusPublished - 1 Feb 2021

Keywords

  • FOXO3a, mRNA expression, Elderly female.

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