The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015

Sotianingsih Haryanto, Rahma F. Hayati, Benediktus Yohan, Lanceria Sijabat, Ifo F. Sihite, Sukmal Fahri, Febrina Meutiawati, Jonathan A.N. Halim, Stefanie N. Halim, Amin Subandrio W. Kusumo, R. Tedjo Sasmono

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Dengue is hyperendemic in Indonesia. In 2015, reported cases of dengue fever doubled those of 2014 in the Jambi municipality of Sumatra. We examined viral aetiology and its relationship with disease outcome in Jambi. Dengue-suspected patients’ sera were collected and NS1 detection and IgM/IgG serology were performed. Dengue virus (DENV) serotyping was performed using real-time RT-PCR. Envelope genes were sequenced to determine the genotypes of DENV. Clinical, haematologic, and demographic data were recorded. Of 210 dengue-suspected patients, 107 were confirmed. The disease manifested as Dengue Fever (62%), Dengue Haemorrhagic Fever (36%), and Dengue Shock Syndrome (2%). The serotypes of 94 DENV were determined. All DENV serotypes were detected with DENV-1 as the predominant serotype (66%). Genotypically, the DENV-1 viruses belong to Genotype I, DENV-2 was of Cosmopolitan genotype, DENV-3 as Genotype I, and DENV-4 belonged to Genotype II. Comparison with historical data revealed serotype predominance switched from DENV-3 to DENV-1, and the replacement of Genotype IV of DENV-1 with Genotype I. In summary, DENV-1 predominated during the 2015 dengue outbreak in Jambi. The full spectrum of dengue disease occurred and was characterized by a switch in predominant serotypes.

Original languageEnglish
Pages (from-to)119-129
Number of pages11
JournalPathogens and Global Health
Issue number3
Publication statusPublished - 2 Apr 2016


  • Dengue
  • Genotype
  • Indonesia
  • Jambi
  • Serotype


Dive into the research topics of 'The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015'. Together they form a unique fingerprint.

Cite this