Low birth weight (LBW) infant is susceptible to health problems since the infant born, during in the hospital and continue after discharge. The purpose of this study was to identify the influence of family empowerment on the health status of LBW infant. Action research using qualitative and quantitative method was used in this study. Qualitative approach was used to identify the experience of mothers of LBW infants as a data based for intervention development, and quantitative approach was used to evaluate the influence of family empowerment program on the health status of LBW infants. There were 7 participants, 20 mothers and their infants in the intervention group and 27 in the control group involved in this study. The study showed that family empowerment was effective in improving the immunization status and follow- up care attendance, reducing the frequency of acute care visits, increasing mothers' knowledge and skill in providing care. In conclusion, mothers need information on providing a proper care for LBW, and family empowerment can significantly improve maternal knowledge and health status of LBW infants.