The influence of chronic prostatic stromal inflammation on benign prostatic hyperplasia progressivity: A retrospective analysis of clinical and histopathology data

Background: Histology of inflammation in benign prostatic hyperplasia (BPH) are common to be found. However, the relationship between the BPH and inflammation is unknown. The aim of this study was to investigate the relationship of prostatic inflammation and BPH progression. Methods: Between June 1994 and December 2013, a total of 500 patients with LUTS clinical and histopathology data were obtained retrospectively from records. Prostatic stromal inflammation was histologically categorized into mild and moderate-severe. Patients with serum PSA >4 ng/ml and biopsy findings other than BPH were excluded. Appropriate statistical analysis was employed. Results: Median age, PSA, and PV were 65 (40–91) years, 2.6 (0.02–4) ng/ml, and 37 (11.4–147) ml respectively. Of all, 69.2% had mild inflammation and 30.8% had severe inflammation. Prostate volume was 36.42 (11.4–147) ml in patients with mild inflammation versus 37.81 (16.2–146.5) ml in patients with moderate-severe inflammation (P = 0.023). There was a statistically significant difference in terms of PV in three different age groups: <60 years-34 (13.4–116.5) ml, 61–70 years–37.4 (11.4 – 146.5) ml, and >70 years-39.2 (16.1–147) ml (P = 0.027). Conclusions: Chronic prostatic stromal inflammation has a role on BPH progression especially in terms of prostate volume.