Nifedipine is used as a medicine for high blood pressure and heart disease. This drug has a short half-life of only 2-6 h and a low bioavailability, so it must be given to obtain the expected therapeutic effect. Therefore, an approach or system is needed for the delivery of therapeutic substances to the target site through a continuously controlled drug release by microencapsulating nifedipine using biodegradable polymers with variety of mass composition using the solvent evaporation method oil in water and using Span 80 as a surfactant that will produce microcapsules. Microcapsules are made with a composition variation of PCL which is higher than the PLLA. The highest percent efficiency of nifedipine encapsulation was obtained in the PLLA: PCL 10:90 (w/w) composition of 87.8 % with yield of 95.3 % and for the highest percent release of drug nifedipine in the PLLA: PCL 40: 60 (w/w) composition at 34.1 % with total release nifedipine 11.0 mg from the total initial nifedipine which is 30.0 mg.