TY - CONF
T1 - The Impact of COVID-19 Vaccination on Disease Severity at a Teaching Hospital in Depok, Indonesia
AU - Salsabila, N.
AU - Handayani, D.
AU - Pratomo, I.P.
AU - Priyonugroho, G.
AU - Sutoyo, D.K.
AU - Imaniar, R.
AU - Wirawan, A.
AU - Baskoro, H.
AU - Zaini, J.
AU - Rozaliyani, A.
AU - Samoedro, E.
AU - Sariwati, E.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Rationale: Up to October 31st 2022, Coronavirus disease (COVID-19) pandemic remained a global emergency with 627,104,342 confirmed cases and 6,567,552 deaths. Study showed that people >65 years old and people with comorbidities including diabetes and heart disease are putat more risk of COVID-19 severity and fatality. Vaccination had become a global strategy inpreventing COVID-19 morbidity, severe disease, and mortality. In early 2022, when booster shots were unavailable for public in Indonesia, only half (50.03%) of Indonesian population had received full dose (2 doses) vaccination. This study aims to explore the relationship between COVID-19 vaccination and disease severity. Method: A retrospective study was conducted with clinical record data of COVID-19 confirmed patients at UIH in February-March 2022, their respective data registered to Reg-covid 19 (a tracking platform for COVID-19 patients) and vaccination data from pedulilindungi.id. There were 269 subjects who have met the inclusion criteria by consecutive sampling. Variables used in this study were vaccination status and the highest disease severity of the patients (Inpatient or Outpatient). Vaccination status was then classified into unvaccinated, partially vaccinated (1 dose), and fully vaccinated (2 doses). Data was analyzed using SPSS statistics version 25 with bivariate analysis. This study was ethically approved by UIH ethical committee. Result: The average age of the subjects was 47.52±19.364 (2SD) years old. As many as 53.9% of subjects were female. Significant relationship was found between age and disease severity using Kruskal-Wallis test (p<0.001) and between gender and disease severity using chi-square test (p=0.017). Result of chi-square test also showed significant relationship between patients’ comorbidities and disease severity (cardiovascular disease p=0.001; RR=2.534; 95%CI=1.438-4.464, diabetes p=0.023; RR=2.046; 95% CI=1.118-3.744). Analysis between vaccination status and disease severity also showed a significant relationship (p<0.001; RR =3.664; 95% CI = 2.112-6.356). Conclusion: There was significant relationship between COVID-19 vaccination and disease severity and also consistent result of significant relationship between cardiovascular disease, diabetes, age, and gender with disease severity.
AB - Rationale: Up to October 31st 2022, Coronavirus disease (COVID-19) pandemic remained a global emergency with 627,104,342 confirmed cases and 6,567,552 deaths. Study showed that people >65 years old and people with comorbidities including diabetes and heart disease are putat more risk of COVID-19 severity and fatality. Vaccination had become a global strategy inpreventing COVID-19 morbidity, severe disease, and mortality. In early 2022, when booster shots were unavailable for public in Indonesia, only half (50.03%) of Indonesian population had received full dose (2 doses) vaccination. This study aims to explore the relationship between COVID-19 vaccination and disease severity. Method: A retrospective study was conducted with clinical record data of COVID-19 confirmed patients at UIH in February-March 2022, their respective data registered to Reg-covid 19 (a tracking platform for COVID-19 patients) and vaccination data from pedulilindungi.id. There were 269 subjects who have met the inclusion criteria by consecutive sampling. Variables used in this study were vaccination status and the highest disease severity of the patients (Inpatient or Outpatient). Vaccination status was then classified into unvaccinated, partially vaccinated (1 dose), and fully vaccinated (2 doses). Data was analyzed using SPSS statistics version 25 with bivariate analysis. This study was ethically approved by UIH ethical committee. Result: The average age of the subjects was 47.52±19.364 (2SD) years old. As many as 53.9% of subjects were female. Significant relationship was found between age and disease severity using Kruskal-Wallis test (p<0.001) and between gender and disease severity using chi-square test (p=0.017). Result of chi-square test also showed significant relationship between patients’ comorbidities and disease severity (cardiovascular disease p=0.001; RR=2.534; 95%CI=1.438-4.464, diabetes p=0.023; RR=2.046; 95% CI=1.118-3.744). Analysis between vaccination status and disease severity also showed a significant relationship (p<0.001; RR =3.664; 95% CI = 2.112-6.356). Conclusion: There was significant relationship between COVID-19 vaccination and disease severity and also consistent result of significant relationship between cardiovascular disease, diabetes, age, and gender with disease severity.
UR - https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A3828
U2 - 10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A3828
DO - 10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A3828
M3 - Abstract
SP - A3828-A3828
T2 - American Thoracic Society 2023 International Conference
Y2 - 19 May 2023 through 24 May 2023
ER -
