The impact of β-hCG on placental angiogenesis in pre-eclampsia

Sri Bekti Subakir, Tri Jauhari, Pramita Iriana, Minarma Siagian, Sutarmo Setiadji

Research output: Contribution to journalArticlepeer-review


Numerous factors, such as VEGF and intra-placental oxygenation, can influence placental angiogenic activity. Early in the normal gestation period, β-hCG enhance VEGF activity to induce angiogenesis. The aims of this study were to identify the correlation between β-hCG concentration in placental culture and placental angiogenic activity in pre-eclampsia. Ten placenta samples from women with pre-eclampsia and 10 from controls (normal pregnancy) were collected. All subjects agreed to participate in this study and signed an informed consent form. β-hCG concentration in supernatant of placental culture was measured by Microparticle Enzyme Immunoassay (MEIA) and placental angiogenic activity was measured by endothelial cell migration toward placental explant (score 0-4). The results showed that the median score of placental angiogenic activity in pre-eclampsia was significantly higher than in normal pregnancy (p<0.05). Concentration of β-hCG in pre-eclampsia was significantly higher than in normal pregnancy (p<0.001). hCG concentration in placental culture was positively correlated to placental angiogenic activity both in pre-eclampsia (r=+0.50) and in normal pregnancy (r=+0.57). Although the correlations were weak, β-hCG is considered one of the factors that influence placental angiogenic activity.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalMedical Journal of Indonesia
Issue number2
Publication statusPublished - 1 Apr 2005


  • Angiogenesis
  • Placenta
  • Pre-eclampsia
  • β-hCG


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