The human pyruvate dehydrogenase complex: a polymorphic region of the lipoate acetyl transferase (E2) subunit gene

Lucky H. Moehario; L. Wang; R. J. Devenish; I. R. Mackay; S. Marzuki

doi:10.1016/0925-4439(91)90096-R

The human pyruvate dehydrogenase complex: a polymorphic region of the lipoate acetyl transferase (E2) subunit gene

Lucky H. Moehario, L. Wang, R. J. Devenish, I. R. Mackay, S. Marzuki

Department of Microbiology Clinic

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. cDNA clones spanning a segment of the 3′-catalytic region of PDH-E2 (nt 1158-1361) have been isolated from human kidney, placenta and bile epithelium cells. Nucleotide sequence analysis of the clones showed differences consistent with the presence of normal variants of PDH-E2 in the human population. However, the existence of tissue-specific isoforms of PDH-E2 cannot yet be discounted.

Original language	English
Pages (from-to)	128-132
Number of pages	5
Journal	BBA - Molecular Basis of Disease
Volume	1097
Issue number	2
DOIs	https://doi.org/10.1016/0925-4439(91)90096-R
Publication status	Published - 23 Sept 1991

Keywords

Biliary cirrhosis
Polymorphism
Pyruvate dehydrogenase complex
cDNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0925-4439(91)90096-R

Cite this

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title = "The human pyruvate dehydrogenase complex: a polymorphic region of the lipoate acetyl transferase (E2) subunit gene",

abstract = "A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. cDNA clones spanning a segment of the 3′-catalytic region of PDH-E2 (nt 1158-1361) have been isolated from human kidney, placenta and bile epithelium cells. Nucleotide sequence analysis of the clones showed differences consistent with the presence of normal variants of PDH-E2 in the human population. However, the existence of tissue-specific isoforms of PDH-E2 cannot yet be discounted.",

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T1 - The human pyruvate dehydrogenase complex

T2 - a polymorphic region of the lipoate acetyl transferase (E2) subunit gene

AU - Moehario, Lucky H.

AU - Wang, L.

AU - Devenish, R. J.

AU - Mackay, I. R.

AU - Marzuki, S.

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AB - A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. cDNA clones spanning a segment of the 3′-catalytic region of PDH-E2 (nt 1158-1361) have been isolated from human kidney, placenta and bile epithelium cells. Nucleotide sequence analysis of the clones showed differences consistent with the presence of normal variants of PDH-E2 in the human population. However, the existence of tissue-specific isoforms of PDH-E2 cannot yet be discounted.

KW - Biliary cirrhosis

KW - Polymorphism

KW - Pyruvate dehydrogenase complex

KW - cDNA

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The human pyruvate dehydrogenase complex: a polymorphic region of the lipoate acetyl transferase (E2) subunit gene

Abstract

Keywords

UN SDGs

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