The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review

David Andi Wijaya; Melva Louisa; Heri Wibowo; Aslim Taslim; Tiara Bunga Mayang Permata; Handoko; Endang Nuryadi; Henry Kodrat; Soehartati Argadikoesoema Gondhowiardjo

doi:10.34172/jhp.2021.18

The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review

David Andi Wijaya, Melva Louisa, Heri Wibowo, Aslim Taslim, Tiara Bunga Mayang Permata, Handoko, Endang Nuryadi, Henry Kodrat, Soehartati Argadikoesoema Gondhowiardjo

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

Original language	English
Pages (from-to)	166-178
Number of pages	13
Journal	Journal of HerbMed Pharmacology
Volume	10
Issue number	2
DOIs	https://doi.org/10.34172/jhp.2021.18
Publication status	Published - 2021

Keywords

Annona muricata
Bioactive compounds
Plant extract
Radio-sensitivity
Radiotherapy

UN SDGs

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10.34172/jhp.2021.18

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Wijaya, D. A., Louisa, M., Wibowo, H., Taslim, A., Permata, T. B. M., Handoko, Nuryadi, E., Kodrat, H., & Gondhowiardjo, S. A. (2021). The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review. Journal of HerbMed Pharmacology, 10(2), 166-178. https://doi.org/10.34172/jhp.2021.18

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title = "The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review",

abstract = "Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.",

keywords = "Annona muricata, Bioactive compounds, Plant extract, Radio-sensitivity, Radiotherapy",

author = "Wijaya, {David Andi} and Melva Louisa and Heri Wibowo and Aslim Taslim and Permata, {Tiara Bunga Mayang} and Handoko and Endang Nuryadi and Henry Kodrat and Gondhowiardjo, {Soehartati Argadikoesoema}",

note = "Funding Information: This study was funded by International Publication Grant from the Universitas Indonesia (grant number NKB-2203/ UN2.RST/HKP.05.00/2020). Publisher Copyright: {\textcopyright} 2021 Nickan Research Institute. All rights reserved.",

year = "2021",

doi = "10.34172/jhp.2021.18",

language = "English",

volume = "10",

pages = "166--178",

journal = "Journal of HerbMed Pharmacology",

issn = "2345-5004",

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Wijaya, DA, Louisa, M , Wibowo, H, Taslim, A, Permata, TBM, Handoko, Nuryadi, E, Kodrat, H & Gondhowiardjo, SA 2021, 'The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review', Journal of HerbMed Pharmacology, vol. 10, no. 2, pp. 166-178. https://doi.org/10.34172/jhp.2021.18

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T1 - The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents

T2 - Proposed mechanisms based on a systematic review

AU - Wijaya, David Andi

AU - Louisa, Melva

AU - Wibowo, Heri

AU - Taslim, Aslim

AU - Permata, Tiara Bunga Mayang

AU - Handoko,

AU - Nuryadi, Endang

AU - Kodrat, Henry

AU - Gondhowiardjo, Soehartati Argadikoesoema

N1 - Funding Information: This study was funded by International Publication Grant from the Universitas Indonesia (grant number NKB-2203/ UN2.RST/HKP.05.00/2020). Publisher Copyright: © 2021 Nickan Research Institute. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

AB - Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

KW - Annona muricata

KW - Bioactive compounds

KW - Plant extract

KW - Radio-sensitivity

KW - Radiotherapy

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DO - 10.34172/jhp.2021.18

M3 - Review article

AN - SCOPUS:85103633859

SN - 2345-5004

VL - 10

SP - 166

EP - 178

JO - Journal of HerbMed Pharmacology

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ER -

The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review

Abstract

Keywords

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