The elusive antifibrotic macrophage

Adhyatmika Adhyatmika, Kurnia Sari Setio Putri, Leonie Beljaars, Barbro N. Melgert

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)

Abstract

Fibrotic diseases, especially of the liver, the cardiovascular system, the kidneys, and the lungs, account for approximately 45% of deaths in Western societies. Fibrosis is a serious complication associated with aging and/or chronic inflammation or injury and cannot be treated effectively yet. It is characterized by excessive deposition of extracellular matrix (ECM) proteins by myofibroblasts and impaired degradation by macrophages. This ultimately destroys the normal structure of an organ, which leads to loss of function. Most efforts to develop drugs have focused on inhibiting ECM production by myofibroblasts and have not yielded many effective drugs yet. Another option is to stimulate the cells that are responsible for degradation and uptake of excess ECM, i.e., antifibrotic macrophages. However, macrophages are plastic cells that have many faces in fibrosis, including profibrotic behavior-stimulating ECM production. This can be dependent on their origin, as the different organs have tissue-resident macrophages with different origins and a various influx of incoming monocytes in steady-state conditions and during fibrosis. To be able to pharmacologically stimulate the right kind of behavior in fibrosis, a thorough characterization of antifibrotic macrophages is necessary, as well as an understanding of the signals they need to degrade ECM. In this review, we will summarize the current state of the art regarding the antifibrotic macrophage phenotype and the signals that stimulate its behavior.

Original languageEnglish
Article number81
JournalFrontiers in Medicine
Volume2
Issue numberNOV
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Antifibrotic
  • Cathepsin K
  • Fibrosis
  • MMP
  • Macrophages
  • Monocytes
  • Polarization
  • Resolution

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