Micro-milling offers high flexibility by producing complex 3D micro-scale products. Weight reduction are one of the optimizations of the product that can make it stronger and more efficient nowadays. Titanium are the most commonly used for micro-scale products especially in biomedical industries because of the biocompatibility properties. Titanium alloys offers high strength with low density and high corrosion resistance that is suitable for weight reduction. This study aims to investigate the influence of high speed cutting parameters to the surface roughness in micromilling of titanium alloy Ti-6Al-4V as high speed cutting offers more productivity since producing more cutting length in the same time. experiments are carried out by micromilling process with variations in high speed cutting parameters of spindle speed and feed rate with a constant depth of cut using a carbide cutting tool of with a diameter of 1 mm. The machining results in the form of a 4 mm slot with a depth as the same as depth of cut, which then measures its surface roughness. It was found that higher feed rate that is followed by higher spindle speed will produce better surface roughness.