TY - JOUR
T1 - The effectiveness of triple-dose albendazole in comparison with mebendazole for the treatment of trichuriasis in children
AU - Sungkar, Saleha
AU - Irmawati, Fanny P.
AU - Haswinzky, Rose A.
AU - Dwinastiti, Yasmine A.
AU - Wahdini, Sri
AU - Firmansyah, Nurhadi E.
AU - Adawiyah, Robiatul
AU - Buntaran, Stanley
AU - Kekalih, Aria
AU - Kusumowidagdo, Gladys
N1 - Funding Information:
This article was presented at The 3rd International Conference and Exhibition on Indonesian Medical Education and Research Institute (ICE on IMERI 2018), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. We thank the Directorate of Research and Public Services Universitas Indonesia who funded this research (Grant no. 2126/UN2. R3.1/HKP.05.00/2018). We also thank headmaster and teachers in Panimbang Village, Pandeglang District, Banten Province who assisted this research. We thank the 3rd ICE on IMERI Committee who had supported the peer review and manuscript preparation before submitting to the journal.
Funding Information:
This study was approved by the Ethical Committee on Health Research, Faculty of Medicine, Universitas Indonesia (protocol No. 626/UN2. F1/ETIK/V/2018). We conducted a randomized controlled trial (RCT) that was preceded by a cross-sectional study to determine the prevalence of trichuriasis. The study was conducted at a primary school in Panimbang Village, Pandeglang District, Banten Province (total sampling), and data were collected in July–August 2018. The subjects’ characteristics, the prevalence of trichuriasis, intensity of infection, CR, and egg reduction rate (ERR) were recorded.
Publisher Copyright:
© 2019 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: Trichuriasis is difficult to treat with single-dose anthelmintic. Although a higher cure rate (CR) can be achieved by treatment with triple-dose albendazole and mebendazole, the results of studies are inconsistent. This study aimed to evaluate the effectiveness of triple-dose albendazole and mebendazole in treating trichuriasis. Methods: A randomized controlled trial was conducted in a primary school in the Pandeglang District, Banten Province, Indonesia in July–August, 2018; 382 children were recruited. Stools were collected and examined microscopically using the Kato–Katz method to identify Trichuriasis eggs. Children positive for Trichuris trichiura were randomized and divided into two groups. One was given a triple dose of 400 mg albendazole and the other a triple dose of 500 mg mebendazole. On day 14 after treatment, stools were reexamined to calculate CR and the egg reduction rate (ERR). Data were analyzed using SPSS version 20. Results: The prevalence of soil-transmitted helminth infection was 42%, and that of trichuriasis and ascariasis was 25.1% and 29.8%. There was a significant difference (Wilcoxon test, P<0.01) in the intensity of infection before and after intervention. Both groups showed high values of CR (mebendazole: 95.2%, albendazole: 85.4%; Fisher’s exact test, P = 0.125) and ERR (mebendazole: 99%, albendazole: 96%; Mann–Whitney test, P = 0.110). There was no significant difference in CR and ERR between the two groups. Conclusion: Triple-dose albendazole was as effective as triple-dose mebendazole in treating trichuriasis.
AB - Objective: Trichuriasis is difficult to treat with single-dose anthelmintic. Although a higher cure rate (CR) can be achieved by treatment with triple-dose albendazole and mebendazole, the results of studies are inconsistent. This study aimed to evaluate the effectiveness of triple-dose albendazole and mebendazole in treating trichuriasis. Methods: A randomized controlled trial was conducted in a primary school in the Pandeglang District, Banten Province, Indonesia in July–August, 2018; 382 children were recruited. Stools were collected and examined microscopically using the Kato–Katz method to identify Trichuriasis eggs. Children positive for Trichuris trichiura were randomized and divided into two groups. One was given a triple dose of 400 mg albendazole and the other a triple dose of 500 mg mebendazole. On day 14 after treatment, stools were reexamined to calculate CR and the egg reduction rate (ERR). Data were analyzed using SPSS version 20. Results: The prevalence of soil-transmitted helminth infection was 42%, and that of trichuriasis and ascariasis was 25.1% and 29.8%. There was a significant difference (Wilcoxon test, P<0.01) in the intensity of infection before and after intervention. Both groups showed high values of CR (mebendazole: 95.2%, albendazole: 85.4%; Fisher’s exact test, P = 0.125) and ERR (mebendazole: 99%, albendazole: 96%; Mann–Whitney test, P = 0.110). There was no significant difference in CR and ERR between the two groups. Conclusion: Triple-dose albendazole was as effective as triple-dose mebendazole in treating trichuriasis.
KW - Albendazole
KW - Cure rate
KW - Egg reduction rate
KW - Mebendazole
KW - Trichuriasis
UR - http://www.scopus.com/inward/record.url?scp=85077148535&partnerID=8YFLogxK
U2 - 10.22159/ijap.2019.v11s6.33559
DO - 10.22159/ijap.2019.v11s6.33559
M3 - Article
AN - SCOPUS:85077148535
SN - 0975-7058
VL - 11
SP - 104
EP - 107
JO - International Journal of Applied Pharmaceutics
JF - International Journal of Applied Pharmaceutics
IS - Special Issue 6
ER -