The effect of three-monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL-5

K. de Ruiter, Dicky Levenus Tahapary, L. J. Wammes, A. E. Wiria, F. Hamid, L. van Lieshout, J. W.A. Smit, J. J. Houwing-Duistermaat, E. Sartono, Taniawati Supali, M. Yazdanbakhsh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is absent. Therefore, we assessed the effect of deworming on Th2-mediated responses in a household-clustered randomized controlled trial in Indonesia. Total plasma IgE and whole-blood IL-5 responses to mitogen phytohaemagglutinin (PHA) were measured in 1494 and 682 subjects, respectively, at baseline, 9 and 21 months after three-monthly single-dose treatment with albendazole or placebo. Anthelmintic treatment did not result in complete removal of helminth infections in the community. However, treatment significantly decreased IgE levels in albendazole- compared to placebo-treated subjects. IL-5 responses to PHA were not significantly affected by anthelmintic treatment and tended to increase in albendazole-treated subjects, indicating that intensive treatment of helminth parasites has different outcomes on B-cell (IgE levels) and T-cell (IL-5) responses. The data shows that 2 years of deworming can have differential effects on responses typified as Th2-mediated, which needs to be taken into account when examining the impact of helminths on noncommunicable diseases.

Original languageEnglish
Article numbere12428
JournalParasite Immunology
Volume39
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • IL-5
  • IgE
  • Indonesia
  • Th2
  • albendazole
  • helminths

Fingerprint Dive into the research topics of 'The effect of three-monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL-5'. Together they form a unique fingerprint.

  • Cite this

    de Ruiter, K., Tahapary, D. L., Wammes, L. J., Wiria, A. E., Hamid, F., van Lieshout, L., Smit, J. W. A., Houwing-Duistermaat, J. J., Sartono, E., Supali, T., & Yazdanbakhsh, M. (2017). The effect of three-monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL-5. Parasite Immunology, 39(6), [e12428]. https://doi.org/10.1111/pim.12428