The Effect of Soybean and Soybean Meal Extract on COX-2 and iNOS Expression in Colon Preneoplasia of Mice Induced by Azoxymethane and Dextran Sodium Sulfate

Wijiasih, Kusmardi, Berna Elya

Research output: Contribution to journalArticle

Abstract

Several studies shows an increase in colon cancer case which is triggered by lifestyle changes in society such as smoking, obesity, high-fat diet, consumption of burned food and lack of fiber consumption. This study objective is to evaluate the inhibition activities of soybean seed extract and soybean meal extract on COX-2and iNOS expressions in colon preneoplasia of mice induced by azoxymethane and dextran sodium sulfate. Swiss Webster mice are injected intraperitoneally by single dose of 10 mg/kg BW azoxymethane and after 7 days followed by administration of 2% dextran sodium sulfatein their drinking for a week. Both extracts are administered orally in three different doses(75 mg / 20 gBW, 150 mg / 20 gBW and 200 mg / 20 gBW) daily for 4 weeks. Immunohistochemical examination is conducted to see the cells with the expression of COX 2 and iNOSin every 1000 epithelial cells. The result shows both the extracts decreases the expression of COX-2 at dose 150 mg / 20 g body weight and 200 mg / 20 g BW significantly with P
Original languageEnglish
Pages (from-to)39-46
JournalInternational Journal of ChemTech Research
Volume10
Issue number1
Publication statusPublished - 1 Dec 2017

Keywords

  • Soybean, Soybean meal, Azoxymethane, Dextran sodium sulfate, COX-2, iNOS

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