TY - JOUR
T1 - The Effect of Solvent Hydrophilicity on the Enzymatic Ring-Opening Polymerization of L-Lactide by Candida rugosa Lipase
AU - Curie, Catia Angli
AU - Darmawan, Muhammad Arif
AU - Dianursanti, Dianursanti
AU - Budhijanto, Wiratni
AU - Gozan, Misri
N1 - Funding Information:
The authors are grateful for the financial support provided through the scheme of Penelitian Dasar (PD) for the 2021 budget year. The funding was granted by the Ministry of Research and Technology/National Research and Innovation Agency of the Republic of Indoneia (NKB-032/UN2.RST/HKP.05.00/2021). We are also grateful for the financial support from Universitas Indonesia through Hibah PUTI Q1 year 2022, grant number NKB-1150/UN2.RST/HKP.05.00/2022.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - Contradictions have been reported on the effect of organic solvents, especially toluene, on enzymatic ring-opening polymerization (eROP) of L-lactide. Studies have shown that log P, a common measure of hydrophilicity, affects enzyme activity. This study examines the effect of solvents with various log P values on the eROP of L-lactide, performed using Candida rugosa lipase (CRL). N,N-dimethylacetamide (DMA), 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, diphenyl ether, and dodecane were used as the organic solvents. The eROP in ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) was also conducted to compare its performance with the organic solvents. The results show that [BMIM][PF6]-mediated eROP gave better conversion and molecular weight than the organic solvent-mediated eROP. In this study, the effects of solvents hydrophilicity are discussed, including the possibility of hexafluorophosphate ion ([PF6]−) hydrolysis to occur.
AB - Contradictions have been reported on the effect of organic solvents, especially toluene, on enzymatic ring-opening polymerization (eROP) of L-lactide. Studies have shown that log P, a common measure of hydrophilicity, affects enzyme activity. This study examines the effect of solvents with various log P values on the eROP of L-lactide, performed using Candida rugosa lipase (CRL). N,N-dimethylacetamide (DMA), 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, diphenyl ether, and dodecane were used as the organic solvents. The eROP in ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) was also conducted to compare its performance with the organic solvents. The results show that [BMIM][PF6]-mediated eROP gave better conversion and molecular weight than the organic solvent-mediated eROP. In this study, the effects of solvents hydrophilicity are discussed, including the possibility of hexafluorophosphate ion ([PF6]−) hydrolysis to occur.
KW - Candida rugosa lipase
KW - enzymatic ring-opening polymerization (eROP)
KW - hydrophilicity
KW - hydrophobicity
KW - ionic liquid
KW - L-lactide
KW - organic solvents
KW - polylactic acid
KW - [BMIM][PF]
KW - [PF] hydrolysis
UR - http://www.scopus.com/inward/record.url?scp=85138836915&partnerID=8YFLogxK
U2 - 10.3390/polym14183856
DO - 10.3390/polym14183856
M3 - Article
AN - SCOPUS:85138836915
SN - 2073-4360
VL - 14
JO - Polymers
JF - Polymers
IS - 18
M1 - 3856
ER -