TY - JOUR
T1 - The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
AU - Krisnamurti, Desak Gede Budi
AU - Farida, Siti
AU - Putri, Rizky Clarinta
AU - Fachri, Wilzar
AU - Purwaningsih, Erni Hernawati
N1 - Funding Information:
The authors would like to acknowledge all staff from the Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, for the continuous support. They also acknowledge the 퀀inancial support from the PUTI grant from Universitas Indonesia with contract number NKB-猃稃礃稂?UN 琁?ST/HKP. 爃省爃爂 球爃球爁?
Funding Information:
The authors would like to acknowledge all staff from the Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, for the continuous support. They also acknowledge the financial support from the PUTI grant from Universitas Indonesia with contract number NKB-1878/UN2.RST/HKP.05.00/2020.
Publisher Copyright:
© The authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0)
PY - 2022/6
Y1 - 2022/6
N2 - Objective: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. Materials and Methods: Twenty-four male Sprague–Dawley rats were induced with a high fructose and cholesterol diet for 4 weeks before being divided into four groups. Each group receiving treatments consisting of simvastatin only, A. indica extracts only, or simvastatin–A. indica extract combination. A histological examination was conducted to determine the effect of each treatment. Also, one-way analysis of variance (ANOVA) and post-hoc Bonferroni test were conducted to assess the comparison of groups from the histological examination. Results: Significant improvement was found in fatty pancreas between rats without therapy and rats treated with simvastatin therapy (p = 0.024, 95% CI: 0.038–0.696), and also between rats without treatment and rats treated with simvastatin–A. indica extract combination therapy (p = 0.000, 95% CI: 0.241–0.873) using one-way ANOVA and the post-hoc Bonferroni test. Conclusions: The results of the combination of simvastatin–A. indica Linn. root extracts treatment showed a synergistic effect on the improvement of fatty pancreas, but further research is needed to find potential adverse effects on the interaction of these two substrates to confirm the safe use of this treatment.
AB - Objective: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. Materials and Methods: Twenty-four male Sprague–Dawley rats were induced with a high fructose and cholesterol diet for 4 weeks before being divided into four groups. Each group receiving treatments consisting of simvastatin only, A. indica extracts only, or simvastatin–A. indica extract combination. A histological examination was conducted to determine the effect of each treatment. Also, one-way analysis of variance (ANOVA) and post-hoc Bonferroni test were conducted to assess the comparison of groups from the histological examination. Results: Significant improvement was found in fatty pancreas between rats without therapy and rats treated with simvastatin therapy (p = 0.024, 95% CI: 0.038–0.696), and also between rats without treatment and rats treated with simvastatin–A. indica extract combination therapy (p = 0.000, 95% CI: 0.241–0.873) using one-way ANOVA and the post-hoc Bonferroni test. Conclusions: The results of the combination of simvastatin–A. indica Linn. root extracts treatment showed a synergistic effect on the improvement of fatty pancreas, but further research is needed to find potential adverse effects on the interaction of these two substrates to confirm the safe use of this treatment.
KW - Acalypha indica linn.
KW - Cholesterol
KW - Fatty pancreas
KW - Fructose
KW - Simvastatin
UR - http://www.scopus.com/inward/record.url?scp=85133517401&partnerID=8YFLogxK
U2 - 10.5455/javar.2022.i601
DO - 10.5455/javar.2022.i601
M3 - Article
AN - SCOPUS:85133517401
SN - 2311-7710
VL - 9
SP - 346
EP - 350
JO - Journal of Advanced Veterinary and Animal Research
JF - Journal of Advanced Veterinary and Animal Research
IS - 2
ER -