The effect of silver nitrate addition on antibacterial properties of bone scaffold chitosan-hydroxyapatite

Muhammad Adli Pratama, Ghiska Ramahdita, Akhmad Herman Yuwono

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Due to a high number of bone fracture cases in Indonesia, the development of bone scaffold is becoming a solution to improve damaged bone structure. In bone scaffold fabrication, several parameters must be met such as morphology, pore size, and antibacterial properties. One of the antibacterial agents that can be used for the bone scaffold is silver nitrate (AgNO3). In this study AgNO3 with various concentrations (0.005, 0.01, 0.02, and 0.1 M) was added in HA-chitosan bone scaffold that was synthesized via freeze drying process. The synthesis resulted in bone scaffolds in the form of an interconnected porous structure. In this study, Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy dispersive x-ray (EDX), and antibacterial test were carried out. SEM-EDX results showed porous morphology with an average size of 68.32 μm in bone scaffold without AgNO3 and 16.66 μm in the bone scaffold with the addition of AgNO3. Antibacterial testing showed that the higher the concentration of silver nitrate used, the greater the diameter of the inhibitory zone produced.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/TerritoryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • Bone Scaffold
  • Chitosan
  • Freeze Drying
  • Hydroxyapatite
  • Silver Nitrate

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