TY - GEN
T1 - The effect of silver nitrate addition on antibacterial properties of bone scaffold chitosan-hydroxyapatite
AU - Pratama, Muhammad Adli
AU - Ramahdita, Ghiska
AU - Yuwono, Akhmad Herman
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/12/10
Y1 - 2019/12/10
N2 - Due to a high number of bone fracture cases in Indonesia, the development of bone scaffold is becoming a solution to improve damaged bone structure. In bone scaffold fabrication, several parameters must be met such as morphology, pore size, and antibacterial properties. One of the antibacterial agents that can be used for the bone scaffold is silver nitrate (AgNO3). In this study AgNO3 with various concentrations (0.005, 0.01, 0.02, and 0.1 M) was added in HA-chitosan bone scaffold that was synthesized via freeze drying process. The synthesis resulted in bone scaffolds in the form of an interconnected porous structure. In this study, Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy dispersive x-ray (EDX), and antibacterial test were carried out. SEM-EDX results showed porous morphology with an average size of 68.32 μm in bone scaffold without AgNO3 and 16.66 μm in the bone scaffold with the addition of AgNO3. Antibacterial testing showed that the higher the concentration of silver nitrate used, the greater the diameter of the inhibitory zone produced.
AB - Due to a high number of bone fracture cases in Indonesia, the development of bone scaffold is becoming a solution to improve damaged bone structure. In bone scaffold fabrication, several parameters must be met such as morphology, pore size, and antibacterial properties. One of the antibacterial agents that can be used for the bone scaffold is silver nitrate (AgNO3). In this study AgNO3 with various concentrations (0.005, 0.01, 0.02, and 0.1 M) was added in HA-chitosan bone scaffold that was synthesized via freeze drying process. The synthesis resulted in bone scaffolds in the form of an interconnected porous structure. In this study, Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy dispersive x-ray (EDX), and antibacterial test were carried out. SEM-EDX results showed porous morphology with an average size of 68.32 μm in bone scaffold without AgNO3 and 16.66 μm in the bone scaffold with the addition of AgNO3. Antibacterial testing showed that the higher the concentration of silver nitrate used, the greater the diameter of the inhibitory zone produced.
KW - Bone Scaffold
KW - Chitosan
KW - Freeze Drying
KW - Hydroxyapatite
KW - Silver Nitrate
UR - http://www.scopus.com/inward/record.url?scp=85076743345&partnerID=8YFLogxK
U2 - 10.1063/1.5139334
DO - 10.1063/1.5139334
M3 - Conference contribution
AN - SCOPUS:85076743345
T3 - AIP Conference Proceedings
BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
A2 - Lischer, Kenny
A2 - Abuzairi, Tomy
A2 - Rahman, Siti Fauziyah
A2 - Gozan, Misri
PB - American Institute of Physics Inc.
T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Y2 - 22 July 2019 through 24 July 2019
ER -