The effect of secang extract (Caesalpinia sappan linn) on the weight and histology appearance of white male rats’ hearts induced by isoproterenol

Objective: This study was conducted to determine the cardioprotective effect of secang extract on the heart cells of rats who suffered from myocardial infarction induced by isoproterenol. Materials and Methods: Sprague Dawley rats were divided into six groups: Normal control, negative control, control extract (200 mg/kg), and three different dose extract groups (50, 100, and 200 mg/kg body weight) that were given treatment for 30 days, and then, induced with isoproterenol. Observations were made for changes in the macroscopic appearance, cardiac weight, and histology of the cardiac organ. Results: The results showed a decrease in the incidence of myocardial infarction in rats given secang extract. The infarction area decreased with increasing doses of extract. The weight of the heart in the control extract group was smaller than in the negative control group. Conclusions: Damage to heart cells, seen in the microscope, decreased with increasing doses.