TY - GEN
T1 - The effect of reaction time on the synthesis of PLA from L-lactide using Candida rugosa lipase and 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) solvent through ring-opening polymerization (ROP)
AU - Anjarsari, Retno Dhita
AU - Curie, Catia Angli
AU - Darmawan, M. Arif
AU - Ramadhan,, M. Yusuf Arya
AU - Gozan, Misri
N1 - Funding Information:
The authors are grateful for the financial support of the present study provided by Penelitian Dasar (PD) for the budget year 2021. The funding was granted by the Ministry of Research and Technology/National Research and Innovation Agency (NKB-032/UN2.RST/HKP.05.00/2021).
Publisher Copyright:
© 2022 Author(s).
PY - 2022/12/5
Y1 - 2022/12/5
N2 - Polylactic Acid (PLA) is a thermoplastic that is used commonly in biomedical applications. It is known for its eco-friendliness, biocompatibility, biodegradability and is made of renewable materials. PLA is usually produced from L-lactide polymerization by the ring-opening polymerization (ROP) method, assisted by a metal-based catalyst. However, metal-based catalyst may leave harmful residue for medical purpose, so non-metal catalyst is needed. Enzyme is one of the best alternatives, especially lipase. The present study carried out the PLA synthesis via the ROP pathway using Candida rugosa lipase in [BMIM][PF6] solvent. The ROP was conducted at 80°C using 5% (w/w) CRL at various reaction time. The longest reaction time used, which was 4 days, lead to highest NMR-estimated number average molecular weight (Mn).
AB - Polylactic Acid (PLA) is a thermoplastic that is used commonly in biomedical applications. It is known for its eco-friendliness, biocompatibility, biodegradability and is made of renewable materials. PLA is usually produced from L-lactide polymerization by the ring-opening polymerization (ROP) method, assisted by a metal-based catalyst. However, metal-based catalyst may leave harmful residue for medical purpose, so non-metal catalyst is needed. Enzyme is one of the best alternatives, especially lipase. The present study carried out the PLA synthesis via the ROP pathway using Candida rugosa lipase in [BMIM][PF6] solvent. The ROP was conducted at 80°C using 5% (w/w) CRL at various reaction time. The longest reaction time used, which was 4 days, lead to highest NMR-estimated number average molecular weight (Mn).
KW - Lipase Candida rugosa
KW - PLA
KW - ROP
KW - [BMIM][PF6]
UR - http://www.scopus.com/inward/record.url?scp=85144505159&partnerID=8YFLogxK
U2 - 10.1063/5.0113588
DO - 10.1063/5.0113588
M3 - Conference contribution
AN - SCOPUS:85144505159
T3 - AIP Conference Proceedings
BT - Proceedings of the 7th International Symposium on Applied Chemistry 2021
A2 - Al Muttaqii, Muhammad
A2 - Kurniawan, Kiki
A2 - Hanafi, Muhammad
A2 - Randy, Ahmad
PB - American Institute of Physics Inc.
T2 - 7th International Symposium on Applied Chemistry 2021, ISAC 2021
Y2 - 28 September 2021 through 30 September 2021
ER -
