The effect of polyethylene glycol on the toxicity properties of functionalized carbon nanotubes with the Variations of Hydrochloric Acid (HCl)

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Abstract

Carbon nanotubes (CNT) are one of the nanotechnologies in the drug delivery system (DDS) because it has high drug loading and targeting delivery capabilities. Pristine CNT are toxic and hydrophobic, so they don't meet the requirements of the DDS. Other researchers have performed CNT functionalization with polyethylene glycol (PEG) by observing cell viability and tumor size without performing toxicity tests. Previous investigators performed a toxic test, but the toxicity of functionalized CNT is (CNTf) still high. This study aims to obtain the effect of the (PEG) addition through secondary functionalization of the toxicity of CNTf. CNT is covalently functionalized through oxidation by HNO3/H2SO4. Variations made are the addition of HCl 8M, HCl 10M, and without HCl addition with sonication at 40oC for 4 hours, followed by PEG addition. CNTf was characterized by FTIR, TGA, UV-Vis Spectroscopy, dispersion tests, and BSLT. The results showed that samples with the PEG addition had formed C-O-C groups originating from PEG. CNTf sample with the HCl 8M/PEG addition produced the highest percentage solubility, which is 49.71%, and the highest LC50 toxicity value of 993.77 ppm. These results indicate that PEG can increase CNT solubility and reduce CNT toxicity. The highest degree of functionalization was generated by CNTf with the PEG addition for 12 hours continuously and without the HCl addition, which is 0.028%. However, CNTf with the PEG addition showed the formation of aggregates in the 29th-day dispersion test.

Original languageEnglish
Pages (from-to)2541-2545
Number of pages5
JournalInternational Journal of Engineering Research and Technology
Volume13
Issue number10
DOIs
Publication statusPublished - 2020

Keywords

  • CNT
  • CNT characterization
  • CNT functionalization
  • CNT toxicity

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