The effect of PM 2.5 exposure on workers’ enzymatic superoxide dismutase (SOD) concentration at a ready-mix concrete factory in 2018

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Abstract

The lungs are exposed to PM 2.5 via inhalation; PM 2.5 then settles in the alveoli and circulates via the blood system, causing chronic obstructive pulmonary disease and cardiovascular issues. PM 2.5 triggers the formation of superoxide anions and provide signals for the formation of superoxide dismutase. Workers at ready-mix concrete factories had long-term exposure to high doses of PM 2.5 . This study investigates the effects of PM 2.5 on the blood SOD concentration of workers.This cross-sectional study involved 53 subjects chosen with random sampling and interviewed to obtain individual characteristic data. PM 2.5 value was measured by gravimetric analysis using High Volume Air Sampler and EPAM-5000. The SOD value was tested with the RanSOD-Kit and read using RX-Monza. Data were analyzed with chi-square and multiple logistic regression.It was determined that the workers exposed to PM2.5 ³65 mg/m3 had a 10x higher risk of obtaining a SOD concentration of <84.40 U/mL than the workers exposed to PM2.5 <65 mg/m3.There is a significant relationship between PM 2.5 exposure and SOD concentration. Working status and length of employment were identified as contributing variables (p-value 0.029; OR 10.165; CI 1.276–90.994). This study suggests that PM 2.5 exposure leads to a decrease in SOD concentration. It is necessary to take preventive measures for workers.

Original languageEnglish
Pages (from-to)344-350
Number of pages7
JournalIndian Journal of Public Health Research and Development
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Keywords

  • Antioxidant
  • Oxidative stress
  • PM
  • Superoxide dismutase

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