The Effect of pH Variation on Fluor-Hydroxyapatite Nano Crystal Synthesis with Microwave Irradiation Method

Hafiz, Nurlely, Y. W. Sari

Research output: Contribution to journalConference articlepeer-review

Abstract

Fluoride-substituted hydroxyapatite (FHA) can be used for biomaterial applications because it has biocompatible properties. FHA is formed by replacing flour ion (F-) with hydroxyl ion (OH-) from hydroxyapatite. This work aims to see the influence of changes in the form of acidity (pH) at the FHA synthesis process using microwave irradiation method. FHA nano-powder was synthesized using a titration of calcium hydroxide solution with diammonium hydrogen phosphate and ammonium fluoride, which will vary the level of fluoride at FHA by 0.9 and 1.3. Subsequently, HCl 1 M or NaOH 1 M to give a variation of pH value. X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray (EDX) spectroscopy analysis techniques were utilized to evaluate the characteristic of synthesized FHA nano-powder. The XRD and FTIR results showed that the powder with pH under control conditions had several additional formed phases such as chlorapatite and carbonate. The value of crystallinity had the distinction of each powder in each pH, but only pH control had crystallinity values, such as tooth enamel. Using the Scherrer formula, the average crystallite size was found around 21-80 nm. SEM and EDX characterization results showed the Ca/P ratio formed was 1.34. The results showed that the addition of acid resulted in the formation of a new phase which dominated and revamped some crystal parameters. Therefore, the synthesis in these conditions is not recommended.

Original languageEnglish
Article number012064
JournalJournal of Physics: Conference Series
Volume1505
Issue number1
DOIs
Publication statusPublished - 15 Jun 2020
Event3rd Annual Scientific Meeting on Medical Physics and Biophysics, PIT-FMB in conjunction with the 17th South-East Asia Congress of Medical Physics, SEACOMP 2019 - Bali, Indonesia
Duration: 8 Aug 201910 Aug 2019

Keywords

  • biomaterial
  • Fluor
  • Fluor-hydroxyapatite
  • pH

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