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The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial

  • Bambang Dwiputra
  • , Ade Meidian Ambari
  • , Dwita Rian Desandri
  • , Budhi Setianto Purwowiyoto
  • , Basuni Radi
  • , Bashar Adi Wahyu Pandhita
  • , Serlie Fatrin
  • , Anwar Santoso

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84–1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88–1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalJournal of Lipid and Atherosclerosis
Volume13
Issue number2
DOIs
Publication statusPublished - May 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Omega-3 fatty acid
  • Secondary prevention

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