TY - JOUR
T1 - The Effect of Omega-3 Supplementation on Heart Failure Outcome
T2 - A Meta-Analysis of Randomized Clinical Trial
AU - Dwiputra, Bambang
AU - Ambari, Ade Meidian
AU - Desandri, Dwita Rian
AU - Purwowiyoto, Budhi Setianto
AU - Radi, Basuni
AU - Pandhita, Bashar Adi Wahyu
AU - Fatrin, Serlie
AU - Santoso, Anwar
N1 - Publisher Copyright:
© 2024 The Korean Society of Lipid and Atherosclerosis.
PY - 2024/5
Y1 - 2024/5
N2 - The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84–1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88–1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.
AB - The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84–1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88–1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Omega-3 fatty acid
KW - Secondary prevention
UR - http://www.scopus.com/inward/record.url?scp=85195117646&partnerID=8YFLogxK
U2 - 10.12997/jla.2024.13.2.89
DO - 10.12997/jla.2024.13.2.89
M3 - Review article
AN - SCOPUS:85195117646
SN - 2287-2892
VL - 13
SP - 89
EP - 96
JO - Journal of Lipid and Atherosclerosis
JF - Journal of Lipid and Atherosclerosis
IS - 2
ER -
