The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate

Kusmardi Kusmardi, Paulus Anthony Halim, Wachid Putranto, Aryo Tedjo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. Method: The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows; Control Group: mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. Result: The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p<0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p<0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p<0.05) compared to the control group. Conclusion: The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.

Original languageEnglish
Pages (from-to)259-266
Number of pages8
JournalPharmacognosy Journal
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 2022

Keywords

  • Azoxymethane
  • Dextran sodium sulfate
  • Fish oil
  • Histopathology
  • Kidney
  • Mice
  • Omega-3

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