TY - GEN
T1 - The effect of hydroxyapatite addition on the mechanical properties of polyvinyl alcohol/chitosan biomaterials for bone scaffolds application
AU - Ramahdita, Ghiska
AU - Puspita, Debie Maya
AU - Albab, Muh Fadhil
AU - Alfata, Rowi
AU - Sofyan, Nofrijon Bin Imam
AU - Yuwono, Akhmad Herman
N1 - Funding Information:
The authors are grateful for the financial support from Directorate Research and Community Engagement-Universitas Indonesia through PITTA grant 2017 with contract no. 0705/SK/R/UI/2017. The authors also would like to thank National Atomic Agency-BATAN for materials supply and collaboration. The support from Department of Metallurgical and Materials Engineering-Universitas Indonesia for laboratory facilities is highly acknowledged.
Publisher Copyright:
© 2018 Author(s). Published by AIP Publishing.
PY - 2018/2/13
Y1 - 2018/2/13
N2 - The increasing number of bone fracture incident in Indonesia from year to year needs an urgent problem solving of the limited bone substitute which can meet the necessary criteria for that purpose. Motivated by this, therefore, the current study is focusing on the optimization of material properties used as bone scaffold. A biomaterial of polyvinyl alcohol (PVA)/chitosan-hydroxyapatite (HA) composite was successfully made by wet chemistry method, followed by freeze thawing and freeze drying. For comparison purposes, the percentage of HA has been varied from 0, 25 and 40 % (wt/v). The resulting composites were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), compressive test, and swelling behavior. The results showed that the addition of HA up to 40% (wt/v) has yielded a porous structure with an average pore size of 42.39 μm. In addition, the compressive modulus was enhanced from 14 MPa for 0% HA to 143, and 191 MPa for composites with the addition of HA from 25 to 40% (wt/v). The addition of HA has also reduced the swelling ratio from 296% for the sample without HA to 85 and 78 % for sample with addition of HA from 25 to 40 (wt/v), respectively. The obtained results show that PVA/chitosan-HA in this study is potential to be used as scaffold in bone tissue engineering.
AB - The increasing number of bone fracture incident in Indonesia from year to year needs an urgent problem solving of the limited bone substitute which can meet the necessary criteria for that purpose. Motivated by this, therefore, the current study is focusing on the optimization of material properties used as bone scaffold. A biomaterial of polyvinyl alcohol (PVA)/chitosan-hydroxyapatite (HA) composite was successfully made by wet chemistry method, followed by freeze thawing and freeze drying. For comparison purposes, the percentage of HA has been varied from 0, 25 and 40 % (wt/v). The resulting composites were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), compressive test, and swelling behavior. The results showed that the addition of HA up to 40% (wt/v) has yielded a porous structure with an average pore size of 42.39 μm. In addition, the compressive modulus was enhanced from 14 MPa for 0% HA to 143, and 191 MPa for composites with the addition of HA from 25 to 40% (wt/v). The addition of HA has also reduced the swelling ratio from 296% for the sample without HA to 85 and 78 % for sample with addition of HA from 25 to 40 (wt/v), respectively. The obtained results show that PVA/chitosan-HA in this study is potential to be used as scaffold in bone tissue engineering.
KW - Composite
KW - Freeze-dry
KW - Freeze-thaw
KW - Hydroxyapatite
KW - PVA/Chitosan
KW - Scaffold
UR - http://www.scopus.com/inward/record.url?scp=85042390008&partnerID=8YFLogxK
U2 - 10.1063/1.5023940
DO - 10.1063/1.5023940
M3 - Conference contribution
AN - SCOPUS:85042390008
T3 - AIP Conference Proceedings
BT - 2nd Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Dhelika, Radon
A2 - Whulanza, Yudan
A2 - Ramahdita, Ghiska
A2 - Wulan, Praswasti P.D.K.
PB - American Institute of Physics Inc.
T2 - 2nd Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2017
Y2 - 25 July 2017 through 26 July 2017
ER -