The effect of hydrogen peroxide (H 2 O 2 ) on carbon nanotubes solubility as drug delivery material for cancer with covalent functionalization

Suryaningrum Pujiastuti, Praswasti P.D.K. Wulan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Currently, the development of carbon nanotubes (CNT) as drug delivery for targeted cancer cells with high efficiency and specificity without causing side effects has become one of the main topics in the nanomedicine. The solubility of CNT has limitations in meeting the standards of the Drug Delivery System (DDS). This study investigated the effect of the addition of H 2 O 2 (hydrogen peroxide) on the solubility of functionalized CNT (f-CNT). The f-CNT was treated covalently using a mixture of acids (HNO 3 , H 2 SO 4 , and HCl). The variations were performed at sonication temperatures of 20, 40, and 60 °C. The best sonication temperature was in the f-CNT which had a high degree of suspension stability and did not damage the morphology of CNT. The f-CNT characterization was performed using Fourier infrared transformation spectroscopy (FTIR), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), thermal gravimetry analysis (TGA), UV-Vis spectroscopy and dispersion tests. The f-CNT sonicated at a temperature of 40 °C with the addition of H 2 O 2 (CS5) produced a purity level of 100%, less-damaged morphology and high suspension stability with an absorbance value of 0.661. The CS5 produced the longest dispersion time, more than 21 days with the highest degree of functionalization, 35.53%.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Country/TerritoryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • carbon nanotubes (CNT)
  • Drug Delivery System
  • functionalization
  • hydrogen peroxide
  • solubility

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