TY - GEN
T1 - The effect of hydrogen peroxide (H
2
O
2
) on carbon nanotubes solubility as drug delivery material for cancer with covalent functionalization
AU - Pujiastuti, Suryaningrum
AU - Wulan, Praswasti P.D.K.
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/9
Y1 - 2019/4/9
N2 -
Currently, the development of carbon nanotubes (CNT) as drug delivery for targeted cancer cells with high efficiency and specificity without causing side effects has become one of the main topics in the nanomedicine. The solubility of CNT has limitations in meeting the standards of the Drug Delivery System (DDS). This study investigated the effect of the addition of H
2
O
2
(hydrogen peroxide) on the solubility of functionalized CNT (f-CNT). The f-CNT was treated covalently using a mixture of acids (HNO
3
, H
2
SO
4
, and HCl). The variations were performed at sonication temperatures of 20, 40, and 60 °C. The best sonication temperature was in the f-CNT which had a high degree of suspension stability and did not damage the morphology of CNT. The f-CNT characterization was performed using Fourier infrared transformation spectroscopy (FTIR), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), thermal gravimetry analysis (TGA), UV-Vis spectroscopy and dispersion tests. The f-CNT sonicated at a temperature of 40 °C with the addition of H
2
O
2
(CS5) produced a purity level of 100%, less-damaged morphology and high suspension stability with an absorbance value of 0.661. The CS5 produced the longest dispersion time, more than 21 days with the highest degree of functionalization, 35.53%.
AB -
Currently, the development of carbon nanotubes (CNT) as drug delivery for targeted cancer cells with high efficiency and specificity without causing side effects has become one of the main topics in the nanomedicine. The solubility of CNT has limitations in meeting the standards of the Drug Delivery System (DDS). This study investigated the effect of the addition of H
2
O
2
(hydrogen peroxide) on the solubility of functionalized CNT (f-CNT). The f-CNT was treated covalently using a mixture of acids (HNO
3
, H
2
SO
4
, and HCl). The variations were performed at sonication temperatures of 20, 40, and 60 °C. The best sonication temperature was in the f-CNT which had a high degree of suspension stability and did not damage the morphology of CNT. The f-CNT characterization was performed using Fourier infrared transformation spectroscopy (FTIR), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), thermal gravimetry analysis (TGA), UV-Vis spectroscopy and dispersion tests. The f-CNT sonicated at a temperature of 40 °C with the addition of H
2
O
2
(CS5) produced a purity level of 100%, less-damaged morphology and high suspension stability with an absorbance value of 0.661. The CS5 produced the longest dispersion time, more than 21 days with the highest degree of functionalization, 35.53%.
KW - carbon nanotubes (CNT)
KW - Drug Delivery System
KW - functionalization
KW - hydrogen peroxide
KW - solubility
UR - http://www.scopus.com/inward/record.url?scp=85064847752&partnerID=8YFLogxK
U2 - 10.1063/1.5096710
DO - 10.1063/1.5096710
M3 - Conference contribution
AN - SCOPUS:85064847752
T3 - AIP Conference Proceedings
BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Wulan, Praswasti P.D.K.
A2 - Gozan, Misri
A2 - Astutiningsih, Sotya
A2 - Ramahdita, Ghiska
A2 - Dhelika, Radon
A2 - Kreshanti, Prasetyanugraheni
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Y2 - 6 August 2018 through 8 August 2018
ER -
