The effect of gypsum extension on a mixture of carboxymethyl chitosan and amorphous calcium phosphate in dental remineralization

Erliyana Yamin, Endang Suprastiwi, Munyati Usman, Sarmayana Sarmayana

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1 Citation (Scopus)


Introduction: Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) is a non-collagenous protein analog material with dentin remineralization ability, and gypsum is a mixing material that facilitates the clinical application. Gypsum is a natural material used to release the regenerative calcium ion and has a good biological response, with osteoconductive, resorbable, and compatible properties. Objectives: The aim of this study was to examine the effect of the addition of gypsum to the non-protein analog material CMC/ACP in dentin remineralization. Material and methods: Tooth samples for this study were taken from patients with tooth impactions at the Maxillofacial Surgery Clinic. Twenty-seven cavities were divided into three groups: Dentin demineralization withAoût any material applied, application of dentin demineralization with CMC/ACP, and application of dentin deminerAâlization with gypsum + CMC/ACP. The results were elucidated on Day 14, using scanning electron microscopy with energy-dispersive X-ray. The data were analyzed using Statistical Package for the Social Sciences version 22 software (IBM Corp., Armonk, NY, USA), analysis of variance (ANOVA) one-way statistic test, and Kruskal-Wallis test. Results: Gypsum showed a positive effect on the ability of CMC/ACP in dentin remineralization. The edge of the dentin tubules appeared to be irregular and smaller, with some covered up. This shows remineralization occurrence after the bio-active material of the CMC/ACP and gypsum application. Conclusions: The addition of gypsum to the CMC/ACP has a positive effect in dentin remineralization.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Stomatology
Issue number2
Publication statusPublished - 8 Jun 2020


  • Amorphous calcium phosphate
  • Calcium
  • Chitosan
  • Gypsum
  • Phosphate


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