The effect of fiber diet on colonic cancer formation: The role of butyrate

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The majority of colon cancers occur sporadically. They are thougth to be caused by non-inherited factors such as a combination of diet and environmental factors, which result in somatic mutations of specific genes. Among dietary factors butyrate which is derived from fermentable fibers may have important role as chemoprotector against colorectal cancer. The source of butyrate in daily diet mostly come from wheat products especially wheat bran. At molecular level, butyrate causes hystone acetylation, favours differentiation, induces apoptosis and regulates the expressions of various oncogens. These effects suggest that butyrate may be protective against colorectal cancers.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalMedical Journal of Indonesia
Issue number2
Publication statusPublished - 1 Apr 2003


  • Apoptosis
  • Colon cancer
  • Dietary fiber


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