TY - GEN
T1 - The effect of fasting on malondialdehyde level in liver and plasma of New Zealand white rabbits
AU - Hardiany, Novi Silvia
AU - Amaanullah, Muhammad Zaki Bariz
AU - Antarianto, Radiana Dhewayani
N1 - Publisher Copyright:
© 2021 Author(s).
PY - 2021/5/25
Y1 - 2021/5/25
N2 - Oxidative stress is a state of imbalance of free radicals in the cells and is one of the causes of various diseases in humans. One method that is thought to reduce oxidative stress is calorie restriction or fasting. However, its effects remain unclear. This study was conducted to determine the effect of intermittent fasting and prolonged fasting on the levels of malondialdehyde (MDA) as an oxidative stress marker in the liver and plasma of New Zealand White rabbits. Fifteen of New Zealand White rabbits were divided into three groups (intermittent fasting (IF), prolonged fasting (PF), and control). MDA was measured in plasma and liver homogenate using spectrophotometry. The results were analyzed using One-way ANOVA test. The liver MDA level was decreased in the IF group, but not significant. However, there was a significant increase in plasma MDA levels both in the IF and PF groups. Moreover, liver MDA level was increased in PF group, although it was not significant. In conclusion, intermittent and prolonged fasting could increase plasma MDA levels significantly.
AB - Oxidative stress is a state of imbalance of free radicals in the cells and is one of the causes of various diseases in humans. One method that is thought to reduce oxidative stress is calorie restriction or fasting. However, its effects remain unclear. This study was conducted to determine the effect of intermittent fasting and prolonged fasting on the levels of malondialdehyde (MDA) as an oxidative stress marker in the liver and plasma of New Zealand White rabbits. Fifteen of New Zealand White rabbits were divided into three groups (intermittent fasting (IF), prolonged fasting (PF), and control). MDA was measured in plasma and liver homogenate using spectrophotometry. The results were analyzed using One-way ANOVA test. The liver MDA level was decreased in the IF group, but not significant. However, there was a significant increase in plasma MDA levels both in the IF and PF groups. Moreover, liver MDA level was increased in PF group, although it was not significant. In conclusion, intermittent and prolonged fasting could increase plasma MDA levels significantly.
UR - http://www.scopus.com/inward/record.url?scp=85107282294&partnerID=8YFLogxK
U2 - 10.1063/5.0052627
DO - 10.1063/5.0052627
M3 - Conference contribution
AN - SCOPUS:85107282294
T3 - AIP Conference Proceedings
BT - International Conference on Life Sciences and Technology, ICoLiST 2020
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Suksuwan, Acharee
A2 - Ng, Chen Siang
A2 - Jemon, Khairunadwa Binti
A2 - Amin, Mohamad
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Wang, I. Ching
A2 - Sunaryono, null
A2 - Zubaidah, Siti
A2 - Aulanni'am, null
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Y2 - 29 September 2020
ER -