The effect of fasting on malondialdehyde level in liver and plasma of New Zealand white rabbits

Novi Silvia Hardiany, Muhammad Zaki Bariz Amaanullah, Radiana Dhewayani Antarianto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Oxidative stress is a state of imbalance of free radicals in the cells and is one of the causes of various diseases in humans. One method that is thought to reduce oxidative stress is calorie restriction or fasting. However, its effects remain unclear. This study was conducted to determine the effect of intermittent fasting and prolonged fasting on the levels of malondialdehyde (MDA) as an oxidative stress marker in the liver and plasma of New Zealand White rabbits. Fifteen of New Zealand White rabbits were divided into three groups (intermittent fasting (IF), prolonged fasting (PF), and control). MDA was measured in plasma and liver homogenate using spectrophotometry. The results were analyzed using One-way ANOVA test. The liver MDA level was decreased in the IF group, but not significant. However, there was a significant increase in plasma MDA levels both in the IF and PF groups. Moreover, liver MDA level was increased in PF group, although it was not significant. In conclusion, intermittent and prolonged fasting could increase plasma MDA levels significantly.

Original languageEnglish
Title of host publicationInternational Conference on Life Sciences and Technology, ICoLiST 2020
EditorsAhmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Acharee Suksuwan, Chen Siang Ng, Khairunadwa Binti Jemon, Mohamad Amin, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440968
DOIs
Publication statusPublished - 25 May 2021
Event3rd International Conference on Life Sciences and Technology, ICoLiST 2020 - Malang, Indonesia
Duration: 29 Sep 2020 → …

Publication series

NameAIP Conference Proceedings
Volume2353
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Country/TerritoryIndonesia
CityMalang
Period29/09/20 → …

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