TY - JOUR
T1 - The effect of environmental temperature on the mammary cancer cells and the infiltrating lymphocytes
AU - Kusmardi, Kusmardi
AU - Felistia, Yuli
AU - Wuyung, Puspita Eka
AU - Kodariah, R. I.A.
AU - Dzakirosin, Dextra F.
N1 - Publisher Copyright:
© 2019, Advanced Scientific Research. All rights reserved.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Purpose: To identify whether temperature has effect on proliferation in the tumor cell (adenocarcinoma) especially in vivo condition Methodology: The experiment was conducted in true experimental design (parallel), in which C3H mice are used, arranged in three cages with different temperatures: 20-22°C, 25-27°C, and 32-34°C in 2 weeks every day for 6 hours each day. The proliferation of the cells was detected with Argyrophilic Nucleolar Organizer Region (AgNOR) staining (mAgNOR and pAgNOR) and lymphocytes were stained with Hematoxylin-Eosin staining. Results: As the result, One-Way ANOVA analysis shows p = 0,000 for mAgNOR and p = 0.000 for pAgNOR. In addition, Mann-Whitney analysis for lymphocyte counts shows p = 0.0241 for both 20-22°C & 25-27°C and 25-27°C & 32-34°C Applications/Originality/Value: The temperature affects cell proliferation in vivo. and number of tumor ilfiltrating lymphocytes.
AB - Purpose: To identify whether temperature has effect on proliferation in the tumor cell (adenocarcinoma) especially in vivo condition Methodology: The experiment was conducted in true experimental design (parallel), in which C3H mice are used, arranged in three cages with different temperatures: 20-22°C, 25-27°C, and 32-34°C in 2 weeks every day for 6 hours each day. The proliferation of the cells was detected with Argyrophilic Nucleolar Organizer Region (AgNOR) staining (mAgNOR and pAgNOR) and lymphocytes were stained with Hematoxylin-Eosin staining. Results: As the result, One-Way ANOVA analysis shows p = 0,000 for mAgNOR and p = 0.000 for pAgNOR. In addition, Mann-Whitney analysis for lymphocyte counts shows p = 0.0241 for both 20-22°C & 25-27°C and 25-27°C & 32-34°C Applications/Originality/Value: The temperature affects cell proliferation in vivo. and number of tumor ilfiltrating lymphocytes.
KW - AgNOR
UR - http://www.scopus.com/inward/record.url?scp=85078926231&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85078926231
SN - 0975-2366
VL - 11
SP - 632
EP - 641
JO - Journal of International Pharmaceutical Research
JF - Journal of International Pharmaceutical Research
ER -
