Purpose: To identify whether temperature has effect on proliferation in the tumor cell (adenocarcinoma) especially in vivo condition Methodology: The experiment was conducted in true experimental design (parallel), in which C3H mice are used, arranged in three cages with different temperatures: 20-22°C, 25-27°C, and 32-34°C in 2 weeks every day for 6 hours each day. The proliferation of the cells was detected with Argyrophilic Nucleolar Organizer Region (AgNOR) staining (mAgNOR and pAgNOR) and lymphocytes were stained with Hematoxylin-Eosin staining. Results: As the result, One-Way ANOVA analysis shows p = 0,000 for mAgNOR and p = 0.000 for pAgNOR. In addition, Mann-Whitney analysis for lymphocyte counts shows p = 0.0241 for both 20-22°C & 25-27°C and 25-27°C & 32-34°C Applications/Originality/Value: The temperature affects cell proliferation in vivo. and number of tumor ilfiltrating lymphocytes.
|Number of pages||10|
|Journal||International Journal of Pharmaceutical Research|
|Publication status||Published - 1 Oct 2019|