The Effect of Centella asiatica Ethanolic Extract on Heart Interleukin-10 Levels of Aged Sprague-Dawley Rats

Muhammad Faris Rizqhilmi, Muhammad Ikrar Hermanadi, Muhammad Yusuf, Rani Wardani Hakim, Siti Farida, Erni Hernawati Purwaningsih

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The rising trend of average life expectancy increased the number of elderly populations. Aging could increase the risk of age-related diseases, such as cardiovascular diseases, through chronic inflammatory process. To inhibit aging, the consumption of herbal plants with anti-inflammatory activity such as Centella asiatica (CA) is preferred. This preliminary study aims to elucidate the effect of CA on heart interleukin-10 (IL-10) levels of aged Sprague-Dawley (SD) rats. Subjects were male SD rats, with aged rats divided into three groups: negative control (placebo), treatment (CA ethanolic extract of 300 mg/kg of body weight), and positive control (6 IU vitamin E); while young rats assigned to comparison control. After 28 days of treatment, all rats were terminated before the concentration of heart IL-10 was measured by ELISA. The obtained data were then analyzed using the Saphiro-Wilk test and one-way ANOVA test. Our result shows CA administration increased heart IL-10 concentration (16.33 ± 2.71 pg/mg in treatment group vs 10.81 ± 0.75 pg/mg in negative control), albeit statistically insignificant. In conclusion, CA ethanolic extract of 300 mg/kg of body weight for 28 days does not affect heart IL-10 levels in aged SD rats.

Original languageEnglish
Title of host publication6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021
EditorsSiti Fauziyah Rahman, Ahmad Zakiyuddin, Yudan Whulanza, Nurul Intan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443716
DOIs
Publication statusPublished - 16 Aug 2022
Event6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 - Depok, Virtual, Indonesia
Duration: 7 Jul 20218 Jul 2021

Publication series

NameAIP Conference Proceedings
Volume2537
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Country/TerritoryIndonesia
CityDepok, Virtual
Period7/07/218/07/21

Keywords

  • aging
  • Centella asiatica
  • heart
  • interleukin-10

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