THE EFFECT OF ANNONA MURICATA LEAVES ON BLOOD GLUCOSE LEVELS SCRATCHING SWISS WEBSTER STRUCTURED BY ALLOXANT

Background: Oxidative stress and inflammatory responses have roles as destructive agents in exacerbating the pathological conditions of diabetes mellitus. The aim of this study was todetermine the effect of the ethanol extract of Annona muricata leaf on reducing glucose levels in alloxan-induced Swiss Webster mice. Methods: This study used 25 Swiss Webster mice which were randomly divided into 5 groups: the Negative Control (NC), Positive Control (PC) group, the treatment group dose 150 mg, 300 mg, 600 mg. Histopathological features will be assessed using the NASH CRN score which will then be processed using SPSS version 24 using the Chi-Square test. While blood glucose levels will be tested using the Kruskal-Wallis test with the post hoc Mann Whitney UTest. Results: While blood glucose levels obtained at the pre-test (H0) compared with the posttest (H14) did not have a significant difference (p = 0.542). The 14th day of the test (H14) between the 5 dose groups did not have a significant difference (p = 0.553). Conclusion: There was no significant relationship in ethanol extract of Annona muricata leaves administration on mice blood glucose level.