The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

Lili Indrawati; Kusmardi Kusmardi; Marwito Wiyanto

doi:10.24871/241202330-34

The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

Lili Indrawati, Kusmardi Kusmardi, Marwito Wiyanto

Department of Pathological Anatomy

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).

Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an experimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.

Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.

Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.

Original language	English
Pages (from-to)	30-34
Journal	The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Volume	24
Issue number	1
DOIs	https://doi.org/10.24871/241202330-34
Publication status	Published - 2023

Keywords

Annona muricata
ICAM-1
VCAM-1
colon carcinogenesis
in vivo

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model",

abstract = "Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an experimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.",

keywords = "Annona muricata, ICAM-1, VCAM-1, colon carcinogenesis, in vivo",

author = "Lili Indrawati and Kusmardi Kusmardi and Marwito Wiyanto",

year = "2023",

doi = "10.24871/241202330-34",

language = "English",

volume = "24",

pages = "30--34",

journal = "The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy",

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T1 - The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

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AU - Kusmardi, Kusmardi

AU - Wiyanto, Marwito

PY - 2023

Y1 - 2023

N2 - Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an experimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.

AB - Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an experimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.

KW - Annona muricata

KW - ICAM-1

KW - VCAM-1

KW - colon carcinogenesis

KW - in vivo

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DO - 10.24871/241202330-34

M3 - Article

SN - 2302-8181

VL - 24

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JO - The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

JF - The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

IS - 1

ER -

The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model

Abstract

Keywords

UN SDGs

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