The effect of acalypha indica L. Root's ethanolic extract on old male sprague-dawley rats' malondialdehyde levels and cognitive function

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Abstract

Abtract. Aging is physiological process characterized by degeneration of body functions and increased oxidative stress level. Malondialdehyde (MDA) is an oxidative stress marker which concentration will rise along with age. Increased level of MDA is associated with tissue aging and degeneration. In other hands, herbal plants are often used as an alternative medication, believed to contain many useful substances. Acalypha indica (AI) is one of the herbal plants that can be found in many regions of Indonesia, therefore AI can be used as a strategic alternative medication considering its availability. As of now, the relationship between AI extract consumption with aging and cognitive function is still unknown. The aim of this study is to assess the effect of ethanolic AI root extract related to aging by measuring MDA level in brain tissue and long-term memory level using Y-maze. Total of 18 old male Sprague-Dawley rats (age 20 - 24 weeks) were divided into 3 groups, which are control group, AI group, and vitamin E group. An additional group consisted of 6 young Sprague-Dawley (age 8 - 12 weeks) rats were used as negative control. Treatment was given to respective group every day for 4 weeks. On the last day of the experiment, the rats were terminat, and their brains were collected to measure MDA level. The results of MDA level analysis were 3,776+1,083 nmol/L for control group, 3,695+0,3947 for AI group, 3,118+0,7845 nmol/L for vitamin E group, and 3,704+0,4624 nmol/L for young rats' group without any significant difference (p=0,5220). The analysis result for weekly data (p=0,3692 for day 7 and p=0,8943 for day 28) and intergroup data (p=0,5000 for control group; p>0,9999 for AI group, vitamin E group, and young rats group) for long term memory also didn't show any significant difference. From the results, it can be concluded that AI extract consumption is not able to decrease MDA levels and slow down cognitive decline.

Original languageEnglish
Title of host publicationRecent Progress on
Subtitle of host publicationEnergy, Communities and Cities - Proceedings of International Symposium on Sustainable and Clean Energy, ISSCE 2019: Quality in Research 2019
EditorsYuliusman Yuliusman, Cindy Dianita
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419896
DOIs
Publication statusPublished - 4 May 2020
Event16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019 - Padang, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2230
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019
CountryIndonesia
CityPadang
Period22/07/1924/07/19

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