TY - JOUR
T1 - The development of novel HPV drugs by HDAC inhibitor based upon applied bioinformatics tool and their specialized algorithm
AU - Puspitasari, Ratih Dyah
AU - Tambunan, Usman Sumo Friend
AU - Dewanto, Gana Lahirin
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/10/15
Y1 - 2019/10/15
N2 - The HPV infection, which is the sole cause of cervical cancer, is a malicious threat for developing countries, for instance, Indonesia. Drug for coping HPV infection have been sold in the market namely SAHA or Vorinostat. Mainly, it works by inhibiting the Human Deacetylase Enzyme (HDAC) class II Homo sapiens. However, due to the contradicting report on its efficacy, a novel drug should be developed to remedy the resistance problem. Some groups have successfully developed novel HDAC inhibitors, based upon computational drug design.
AB - The HPV infection, which is the sole cause of cervical cancer, is a malicious threat for developing countries, for instance, Indonesia. Drug for coping HPV infection have been sold in the market namely SAHA or Vorinostat. Mainly, it works by inhibiting the Human Deacetylase Enzyme (HDAC) class II Homo sapiens. However, due to the contradicting report on its efficacy, a novel drug should be developed to remedy the resistance problem. Some groups have successfully developed novel HDAC inhibitors, based upon computational drug design.
KW - Bioinformatics
KW - HPV
KW - SAHA
UR - http://www.scopus.com/inward/record.url?scp=85073785844&partnerID=8YFLogxK
U2 - 10.33263/BRIAC95.428432
DO - 10.33263/BRIAC95.428432
M3 - Review article
AN - SCOPUS:85073785844
SN - 2069-5837
VL - 9
SP - 4428
EP - 4432
JO - Biointerface Research in Applied Chemistry
JF - Biointerface Research in Applied Chemistry
IS - 5
ER -