The development of novel HPV drugs by HDAC inhibitor based upon applied bioinformatics tool and their specialized algorithm

Ratih Dyah Puspitasari, Usman Sumo Friend Tambunan, Gana Lahirin Dewanto

Research output: Contribution to journalReview article

Abstract

The HPV infection, which is the sole cause of cervical cancer, is a malicious threat for developing countries, for instance, Indonesia. Drug for coping HPV infection have been sold in the market namely SAHA or Vorinostat. Mainly, it works by inhibiting the Human Deacetylase Enzyme (HDAC) class II Homo sapiens. However, due to the contradicting report on its efficacy, a novel drug should be developed to remedy the resistance problem. Some groups have successfully developed novel HDAC inhibitors, based upon computational drug design.

Original languageEnglish
Pages (from-to)4428-4432
Number of pages5
JournalBiointerface Research in Applied Chemistry
Volume9
Issue number5
DOIs
Publication statusPublished - 15 Oct 2019

Keywords

  • Bioinformatics
  • HPV
  • SAHA

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