The HPV infection, which is the sole cause of cervical cancer, is a malicious threat for developing countries, for instance, Indonesia. Drug for coping HPV infection have been sold in the market namely SAHA or Vorinostat. Mainly, it works by inhibiting the Human Deacetylase Enzyme (HDAC) class II Homo sapiens. However, due to the contradicting report on its efficacy, a novel drug should be developed to remedy the resistance problem. Some groups have successfully developed novel HDAC inhibitors, based upon computational drug design.