Electronic signature should accelerate and protect the electronic transactions in government agencies and non-governmental organizations, but its adoption is slow. Until the beginning of 2020, the number of organizations that utilize electronic signature is still very small compared to the number of organizations that have online service. This study aims to identify factors that determine employees in the organization to continue or are interested in utilizing electronic signature. The electronic signature referred to in this study is a certified electronic signature or digital signature. The survey was conducted on users and prospective users in government agencies and non-government organizations. The research uses an integrated framework Technology Acceptance Model (TAM) and Technology-Organization-Environment (TOE) in the information systems discipline. Based on 192 responses, the research framework is validated. Seven driving factors were successfully identified. The seven driving factors are security protection, internal need, training and education, government policy, vendor support, perceived ease of use, and perceived usefulness. The results of this study expand research on the adoption of electronic signature, and broaden research on technology acceptance models, specifically the TAM-TOE integration model. The findings of this study can be input for the government, electronic signature vendors, and organizations to increase the utilization of electronic signature.