TY - JOUR
T1 - The correlation between thrombopoietin and platelet count in adult dengue viral infection patients.
AU - Matondang, Asnath Vera
AU - Widodo, Djoko
AU - Zulkarnain, Iskandar
AU - Rengganis, Iris
AU - Trihandini, Indang
AU - Inada, Katsuya
AU - Endo, Shigeatsu
PY - 2004
Y1 - 2004
N2 - AIM: To investigate alteration in humoral regulation during the course of dengue viral infection. METHODS: A prospective analytic study had been conducted involving 40 subjects with dengue viral infection. Subjects were recruited according to consecutive non-probability sampling. Subjects were categorized according to days of illness, platelet counts and serum thrombopoietin (TPO) levels. The plasma TPO levels examinations were done once daily until the platelet counts reached more than 100,000/mm(3). RESULTS: Statistical analysis showed the mean serum TPO levels were increased during thrombocytopenia phase of the disease, and differ significantly from the convalescent phase (mean value 428 pg/ml vs 220.1 pg/ml, p= 0.00). There was also a statistically significant inverse correlation between serum TPO levels and platelet counts (p= 0.00). CONCLUSION: TPO levels were significantly increased in adult patients with dengue infection in which platelets in circulation were markedly reduced, and the TPO levels were inversely related to the platelet counts.
AB - AIM: To investigate alteration in humoral regulation during the course of dengue viral infection. METHODS: A prospective analytic study had been conducted involving 40 subjects with dengue viral infection. Subjects were recruited according to consecutive non-probability sampling. Subjects were categorized according to days of illness, platelet counts and serum thrombopoietin (TPO) levels. The plasma TPO levels examinations were done once daily until the platelet counts reached more than 100,000/mm(3). RESULTS: Statistical analysis showed the mean serum TPO levels were increased during thrombocytopenia phase of the disease, and differ significantly from the convalescent phase (mean value 428 pg/ml vs 220.1 pg/ml, p= 0.00). There was also a statistically significant inverse correlation between serum TPO levels and platelet counts (p= 0.00). CONCLUSION: TPO levels were significantly increased in adult patients with dengue infection in which platelets in circulation were markedly reduced, and the TPO levels were inversely related to the platelet counts.
UR - http://www.scopus.com/inward/record.url?scp=21744437456&partnerID=8YFLogxK
M3 - Article
C2 - 15673939
AN - SCOPUS:21744437456
SN - 0125-9326
VL - 36
SP - 62
EP - 69
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 2
ER -