The correlation between thrombopoietin and platelet count in adult dengue viral infection patients.

Asnath Vera Matondang, Djoko Widodo, Iskandar Zulkarnain, Iris Rengganis, Indang Trihandini, Katsuya Inada, Shigeatsu Endo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

AIM: To investigate alteration in humoral regulation during the course of dengue viral infection. METHODS: A prospective analytic study had been conducted involving 40 subjects with dengue viral infection. Subjects were recruited according to consecutive non-probability sampling. Subjects were categorized according to days of illness, platelet counts and serum thrombopoietin (TPO) levels. The plasma TPO levels examinations were done once daily until the platelet counts reached more than 100,000/mm(3). RESULTS: Statistical analysis showed the mean serum TPO levels were increased during thrombocytopenia phase of the disease, and differ significantly from the convalescent phase (mean value 428 pg/ml vs 220.1 pg/ml, p= 0.00). There was also a statistically significant inverse correlation between serum TPO levels and platelet counts (p= 0.00). CONCLUSION: TPO levels were significantly increased in adult patients with dengue infection in which platelets in circulation were markedly reduced, and the TPO levels were inversely related to the platelet counts.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalActa medica Indonesiana
Volume36
Issue number2
Publication statusPublished - 1 Jan 2004

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